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  • Title: [Interaction of heavy and light chains of plasmin with fibrinogen E and D fragments].
    Author: Kudinov SA, Lezhen TI.
    Journal: Biokhimiia; 1984 Dec; 49(12):2003-7. PubMed ID: 6240993.
    Abstract:
    It was demonstrated that plasminogen and the plasmin heavy chain form a complex with an immobilized fibrinogen fragment E. The E-fragment interacts, in its turn, with the immobilized heavy chain; this interaction is provided for by the lysin binding sites of the plasminogen molecule. The plasmin light chain having no lysin binding sites is specifically absorbed on the immobilized fragment D, whereas the D-fragment--on the immobilized light chain. The elution is caused by arginine or benzamidine; 6-aminohexanoic acid does not affect this interaction. It is assumed that the interaction of plasminogen and plasmin with fibrin is provided for not only by the lysine binding but also by the benzamidine binding sites of the plasminogen molecule.
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