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  • Title: Effects of hematoporphyrin (HPD) and a chemiluminescence system on the growth of transplanted tumors in C3H/HeJ mice.
    Author: Phillip MJ, McMahon JD, O'Hara MD, Hetzel FW, Amsterdamsky C, Schaap AP.
    Journal: Prog Clin Biol Res; 1984; 170():563-9. PubMed ID: 6241697.
    Abstract:
    Photoradiation therapy is emerging as a promising technique for combating cancer. Fundamentally, this approach consists of two steps: hematoporphyrin derivative (HPD) is used to selectively sensitize cancer cells to visible light; after an appropriate time interval, light is introduced into the tumor via a laser-fiber optic system to trigger the cytotoxic action of HPD. The present investigation was initiated to determine the therapeutic potential of HPD in combination with a chemiluminescent activator in treating mice which had been transplanted with tumors.
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