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  • Title: [Studies of the kinetics of bone concentration of mdp-tc 99m in Paget's disease and various treatment methods].
    Author: de La Rochefoucauld B, Basset JY, Rondier J, Cayla J, Ancri D.
    Journal: Rev Rhum Mal Osteoartic; 1984 Nov; 51(10):575-9. PubMed ID: 6241965.
    Abstract:
    We did 27 bone scintiscans in 20 patients, 15 of whom had Paget's disease. Early variations of isotopic activity were analyzed in the pagetic bone, and in normal bone and muscle tissue using 3 parameters: A1 or the period of maximum activity obtained when the isotope was first injected into the circulation, A2 or the isotopic activity at 30 minutes, and P or slope of the curve in the change of activity between 15 and 30 minutes. These scintigraphic parameters, which seem to reflect the importance of the vascular phase (parameter A1) and of the metabolic activity of the bone (parameter A2/A1 and P) proved to be a good guide in following the course of Paget's disease. In 6 patients with Paget's disease who were treated with calcitonin (5 cases) or by etidronate disodium (1 case), we compared the changes in these isotopic parameters with the clinical and laboratory findings before and after treatment. We were able to note a good correlation between the clinical course of the illness and the scintiscans in most cases.
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