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  • Title: The effect of dietary protein on the biological activity of cholecalciferol and its metabolites in the rachitic rat.
    Author: Raghuramulu N, DeLuca HF.
    Journal: J Nutr; 1980 Jan; 110(1):28-34. PubMed ID: 6243702.
    Abstract:
    Rats maintained on low-protein rachitogenic diets show increased intestinal calcium transport, serum inorganic phosphate and increased endochondral calcification responses to calciferol, 25-hydroxycholecalciferol (25-OH-CC) and 1,25-dihydroxycholecalciferol (1,25-(OH)2CC). Because enhanced responses are observed with 1,25-dihydroxycholecalciferol as well as its precursors, it is unlikely that the effect of dietary protein is mediated by a change in the calciferol-25-hydroxylase and the 25-hydroxycholecalciferol-1 alpha-hydroxylase. Instead, it appears that either metabolism of 1,25-dihydroxycholecalciferol or its activity in the target organs is affected.
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