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  • Title: [Effect of bonaphthone on embryogenesis in white rats and mice].
    Author: Proïnova VA, Pershin GN, Shashkina LF, Golubeva MI.
    Journal: Farmakol Toksikol; 1978; 41(1):109-14. PubMed ID: 624381.
    Abstract:
    Results of testing the embryotropic activity of bonaphthone used in different doses (700; 400; 100; 50 and 2 mg/kg) are reported. With its oral introduction to pregnant rats bonaphthone, given in doses at the level of the therapeutid one (2 mg/kg) and exceeding it by as much as 25 times (50 mg/kg), was found not to produce any damaging effect on the fetus. With its action in doses of 100 and 400 mg/kg a slight embryotoxic effect was noted. In the sublethal dose of 700 mg/kg the preparation displays a moderate embryotoxic action and produces a number of circulatory changes in the fetuses. It is concluded that bonaphthone displays no teratogenic properties.
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