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  • Title: [Effect of cholagogic agents on volumetric natriuresis in rats with experimental dystrophy of the liver].
    Author: Iakovlev VE.
    Journal: Farmakol Toksikol; 1978; 41(1):73-6. PubMed ID: 624393.
    Abstract:
    In experimental dystrophy of the liver in rats provoked by introduction of CCL4 the enlargement of the extracellular space is followed by a diminished excretion of sodium. Administration against this background of cholagogues--dehydrocholic acid (250 mg/kg), flaminum (50 mg/kg) and sodium selenite (30 mg/kg) for a space of 7 days helps restore the volumetric natriuresis. It may be assumed that in experimental dystrophy of the liver the process of formation of the natriuretic factor in the liver is deranged. Introduction of the cholagogues under study helps re-establish its formation. Under these circumstances the sensitivity of the rats' kidneys to the natriuretic factor remains practically unchanged.
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