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  • Title: Autoradiographic localization of gamma-aminobutyric acid (GABA) receptors in the rat cerebellum.
    Author: Palacios JM, Young WS, Kuhar MJ.
    Journal: Proc Natl Acad Sci U S A; 1980 Jan; 77(1):670-4. PubMed ID: 6244575.
    Abstract:
    [3H]Muscimol was used in the light microscopic autoradiographic localization of gamma-aminobutyric acid (GABA) receptors in the rat cerebellum. The binding of [3H]-muscimol to the slide-mounted tissue sections had all of the characteristics associated with a GABA receptor. It was saturable with appropriate kinetic constants and was blocked only by other GABAergic drugs. Autoradiographic studies revealed a very high density of receptors over the granule cell layer, a low level over the molecular layer, and negligible receptor binding over white matter. This suggested a high localization of GABA receptors to granule cells, which is supported by other neurochemical studies. The autoradiographic procedure used here should be a useful method in further studies of receptors requiring high sensitivity and increased anatomical resolution.
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