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  • Title: Characterization of polyoma viral DNA sequences in polyoma-induced hamster tumor cell lines.
    Author: Israel MA, Vanderryn DF, Meltzer ML, Martin MA.
    Journal: J Biol Chem; 1980 Apr 25; 255(8):3798-805. PubMed ID: 6245092.
    Abstract:
    The polyoma (PY) viral DNA sequences present in a series of hamster tumor cell lines were evaluated using the blotting technique of Southern ((1975) J. Mol. Biol. 98, 503-517). Remarkably, no cell line contained an intact distal portion of the early gene region which encodes a portion of the large T antigen. All cell lines examined contained the PY DNA Bum I fragment which contains most of the genetic information encoding PY small and middle T antigens, as well as the origin of viral DNA replication. These results provide an explanation for our previous observation that PY virus-induced hamster tumors do not contain the large species of T antigen.
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