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  • Title: Antibiotics in the treatment of gastroenteritis caused by enteropathogenic Escherichia coli.
    Author: Thorén A, Wolde-Mariam T, Stintzing G, Wadström T, Habte D.
    Journal: J Infect Dis; 1980 Jan; 141(1):27-31. PubMed ID: 6245145.
    Abstract:
    The role of antibiotics in treating endemic infantile diarrhea caused by enteropathogenic Escherichia coli has not been determined. In a controlled study of 49 patients, one group received mecillinam and another group received trimethoprim-sulfamethoxazole. A third group served as control subjects. Serotype O111:B4 dominated. Treatment, as evaluated clinically on the third day, resulted in cure for 79% of those receiving mecillinam, 73% of those receiving trimethoprim-sulfamethoxazole, and 7% of the control subjects. Bacteriologic cure was confirmed in 53%, 53%, and 0, respectively. The statistically significant difference between antibiotic-treated patients and control subjects (P less than 0.001) indicated that antibiotics are an important supplement in the treatment of endemic severe diarrhea caused by enteropathogenic E. coli.
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