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  • Title: Tumor-promoting phorbol esters stimulate hematopoietic colony formation in vitro.
    Author: Stuart RK, Hamilton JA.
    Journal: Science; 1980 Apr 25; 208(4442):402-4. PubMed ID: 6245446.
    Abstract:
    Tumor-promoting phorbol esters stimulated mouse bone marrow cells to form myeloid colonies in agar cultures without added colony-stimulating factors. The colony-stimulating ability of various phorbol esters correlated well with their ability to promote skin tumors in vivo. These results suggest that phorbol esters mimic the action of specific colony-stimulating factors that regulate growth.
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