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  • Title: Lateral mobility of beta-receptors involved in adenylate cyclase activation.
    Author: Atlas D, Volsky DJ, Levitzki A.
    Journal: Biochim Biophys Acta; 1980 Mar 27; 597(1):64-9. PubMed ID: 6245689.
    Abstract:
    Cationized ferritin was found to inhibit the lateral mobility of intramembrane proteins in turkey erythrocyte membranes and the activation of adenylate cyclase by the (--)-epinephrine-bound beta-adrenergic receptor. It was observed that cationized ferritin has only a small direct effect on the beta-receptor and on the adenylate cyclase moiety. It is concluded that the cationized ferritin-induced inhibition of the hormone-dependent cyclase activity results from the inhibition of the lateral mobility of the receptor and therefore a decrease in the bimolecular rate of interaction between the receptor and the enzyme.
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