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  • Title: Studies on the mode of action of calciferol XXV. 1 alpha,25-dihydroxy-5,6-trans-vitamin D3, the 5E-isomer of 1 alpha,25-dihydroxyvitamin D3.
    Author: Wecksler WR, Norman AW.
    Journal: Steroids; 1980 Apr; 35(4):419-25. PubMed ID: 6246662.
    Abstract:
    A structural analog of 1 alpha,25-dihydroxyvitamin D3 has been examined for biological activity and its ability to interact with the 1 alpha,25-dihydroxyvitamin D3 receptor system from chick intestine. This steroid, 1 alpha,25-dihydroxy-5,6-trans-vitamin D3, is the 5E-isomer of the parent molecule which differs from that molecule only in the position of the exocyclic C-19 methylene group. This new compound allows for the first direct assessment of the relative contribution of this A-ring substituent to ligand-receptor interaction and biological activity. This analog was found to be 6--12% as biologically active as the parent hormone and 13% as effective in binding to the intestinal receptor.
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