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  • Title: Cardiac beta-adrenoceptors and adenylyl cyclase activity in rabbit heart during conditions of altered sympathetic activity.
    Author: Bobik A, Korner P, Carson V, Oliver JR.
    Journal: Circ Res; 1980 Jun; 46(6 Pt 2):I43-4. PubMed ID: 6247093.
    Abstract:
    Chronic (2 weeks) guanethidine treatment of rabbits depleted left ventricular noradrenaline and increased sarcolemmal beta-receptor density and protein yield. Total adenylyl cyclase activity was unchanged. Chronic sinoaortic denervation did not affect ventricular catecholamines and only marginally reduced beta-receptor numbers.
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