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  • Title: Age and beta adrenoceptor-mediated function.
    Author: Dillon N, Chung S, Kelly J, O'Malley K.
    Journal: Clin Pharmacol Ther; 1980 Jun; 27(6):769-72. PubMed ID: 6247116.
    Abstract:
    Beta adrenoceptor-mediated responsiveness to isoproterenol was compared in young and old subjects using the production of cyclic adenosine monophosphate (cyclic AMP) by lymphocytes as an index. The mean log dose-response curve for the elderly group was displaced to the right and the mean maximum response was less than that for the young subjects. The results corroborate evidence of a decreased response to isoproterenol-induced increases in heart rate in the elderly and raise the possibility of a generalized decrease in beta adrenoceptor-mediated functions in old age.
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