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  • Title: Elicitation of anti-viral cytotoxic T lymphocytes with purified viral and H-2 antigens.
    Author: Hale AH, Ruebush MJ, Harris DT.
    Journal: J Immunol; 1980 Jul; 125(1):428-30. PubMed ID: 6247399.
    Abstract:
    The minimal molecular requirements for elicitation of secondary anti-Sendai virus CTL were investigated. The hemagglutinin-neuraminidase (HN) glycoprotein of Sendai virus and the H-2Kk glycoprotein of YAC tumor cells were purified and incorporated into phospholipid vesicles. These unilamellar liposomes were then tested for the ability to elicit H-2 restricted secondary anti-Sendai virus CTL. The results indicate that these well-defined vesicles were capable of eliciting secondary anti-Sendai virus CTL which lysed only target cells possessing the H-2Kk haplotype and modified with inactivated Sendai virus.
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