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  • Title: A re-evaluation of the mechanisms underlying simple cell orientation selectivity.
    Author: Sillito AM, Kemp JA, Milson JA, Berardi N.
    Journal: Brain Res; 1980 Aug 04; 194(2):517-20. PubMed ID: 6248171.
    Abstract:
    Following from evidence supporting GABA as a putative inhibitory transmitter in the visual cortex, we have iontophoretically applied the GABA antagonist N-methyl bicuculline (Nmb) to simple cells in order to block the inhibitory inputs acting on them. We found that under these conditions previously sharply-tuned simple cells responded equally to all orientations. Moreover receptive field dimensions, judged by the response to stimuli at the optimal and orthogonal orientations, equated best with that expected from a single dLGN cell input. It seems thus, that asymmetries in the excitatory input are not a significant factor in the generation of simple cell orientation selectivity. The asymmetry underlying orientation selectivity rather originates from the operation of an intracortical inhibitory mechanism.
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