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  • Title: In vitro construction of a B-tropic virus by recombination: B-tropism is a cryptic phenotype of xenotropic murine retroviruses.
    Author: Gautsch JW, Elder JH, Jensen FC, Lerner RA.
    Journal: Proc Natl Acad Sci U S A; 1980 May; 77(5):2989-93. PubMed ID: 6248877.
    Abstract:
    A B-tropic virus was isolated in vitro from the progeny of mouse cells doubly infected with N-tropic and xenotropic murine leukemia viruses. Biological and structural evidence is presented suggesting that the phenotypically silent structural marker for B-tropism, expressed by the xenotropic virus p30, was transferred to an N-ecotropic virus via recombination, thus resulting in the expression of a B-ecotropic murine leukemia virus.
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