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  • Title: Pharmacology of guanfacine.
    Author: Scholtysik G.
    Journal: Br J Clin Pharmacol; 1980; 10 Suppl 1(Suppl 1):21S-24S. PubMed ID: 6249333.
    Abstract:
    1. The pharmacological effects of the centrally acting antihypertensive drug guanfacine are reviewed. 2. The drug lowers systemic blood pressure in hypertensive rats dose-dependently after oral application of 0.3-5 mg/kg. 3. Evidence is presented that guanfacine produces its antihypertensive action by a specific stimulation of central alpha-adrenoceptors. 4. Certain pharmacological differences between clonidine and guanfacine are discussed.
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