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  • Title: 'gamma-MSH' fragments from ACTH-beta-LPH precursor have an affinity for opiate receptors.
    Author: Oki S, Nakao K, Nakai Y, Ling N, Imura H.
    Journal: Eur J Pharmacol; 1980 Jun 13; 64(2-3):161-4. PubMed ID: 6249615.
    Abstract:
    gamma-Melanotropin (gamma-MSH), a putative peptide residing in the cryptic N-terminal portion of ACTH-beta-LPH precursor, shares several amino acid residues with alpha-MSH or beta-MSH. The present study revealed that gamma-MSH and structurally related peptides had as potent an affinity for rat brain opiate receptors as did ACTH1-24 when 3H-naloxone was used as a ligand. Thus, gamma-MSH and structurally related peptides may have physiological significance in the activities of the CNS.
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