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  • Title: Rearrangement of chloramphenicol-3-monosuccinate.
    Author: Brent DA, Chandrasurin P, Ragouzeos A, Hurlbert BS, Burke JT.
    Journal: J Pharm Sci; 1980 Aug; 69(8):906-8. PubMed ID: 6249906.
    Abstract:
    The equilibrium mixture of chloramphenicol-3-monosuccinate and its alternate form at neutral pH in aqueous solution was reexamined. The structure of the alternate form was shown by mass specxtrometry and NMR spectroscopy to be chloramphenicol-1-monosuccinate and not the cyclic hemi-ortho ester reported previously.
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