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  • Title: [Primary liver carcinoma and markers of virus of type B hepatitis (author's transl)].
    Author: Pedreira JD, Vargas V, Vilaseca J, Esteban R, Hernández-Sánchez JM, Guardia J, Bacardi R.
    Journal: Med Clin (Barc); 1980 Jun 25; 75(2):58-60. PubMed ID: 6249978.
    Abstract:
    Association of primary liver carcinoma with virus of type B hepatitis has been demonstrated around the world, especially in African and Asian countries where high titles for surface antigen of B hepatitis (HBsAg) have been found. Presence of viral markers of B hepatitis has been studied in a group of 34 patients with primary liver carcinoma, in 139 cirrhotic patients, and in 100 normal individuals. Positive titles of HBsAg or of antibodies against "core" antigen (anti-HBc) without evidence of antibodies against HBsAg (anti-HBs) were considered as positive markers for virus B infection. Percentages of positive markers in the series studied were as follows: 52% in the cases of primary liver carcinoma, 38% in the cirrhotic cases, and 5% in the control subjects. There is a significant difference in relation to the incidence of viral markers between patients with liver carcinoma and normal controls. A possible role of the virus of B hepatitis in the pathogenesis of primary liver carcinoma could be suggested on the basis of these results.
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