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  • Title: Small intestinal epithelial brush border enzymatic changes in suckling mice infected with reovirus type 3.
    Author: Branski D, Lebenthal E, Faden H, Hatch TF, Krasner J.
    Journal: Pediatr Res; 1980 Jun; 14(6):803-5. PubMed ID: 6250121.
    Abstract:
    Suckling mice infected with reovirus type 3 were examined for changes in the epithelial brush border of the small intestine. After 3 days of infection with reovirus type 3, no significant changes were found in intestinal morphology or activity of any enzymes tested. After 6 days, villi were shortened and blunted with lymphangiectatic lesions and mild mononuclear infiltration in the lamina propria. In addition, there was a significant decrease in lactase (P < 0.001) and enterokinase activity (P < 0.05). However, there were no significant changes in the activities of alkaline phosphatase. In contrast, maltase (P < 0.001) and leucine aminopeptidase (P < 0.05) activities in the infected mice were significantly increased. These data suggest that brush border enzymes are affected differently by reovirus infection.
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