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  • Title: [Demonstration of Epstein-Barr virus genome in european Burkitt lymphoma (author's transl)].
    Author: Wutzler P, Sprössig M, Hirsch J, Brichaćek B, Vonka V, Schindler E, Wutke K, Rüdiger KD, Wöckel W.
    Journal: Dtsch Med Wochenschr; 1980 Jul 04; 105(27):961-6. PubMed ID: 6250783.
    Abstract:
    A 6-year-old European boy with a tumour in the head and neck region died 86 days after the first occurrence of symptoms despite chemo- and radiotherapy. An epipharyngeal biopsy at the beginning of the disease and a cytological investigation of biopsy and autopsy material showed non-Hodgkin lymphoma with a high degree of malignancy of the Burkitt type. High antibody titres against Epstein-Barr virus (EBV)-specific virus capsid antigen, nuclear antigen and the R component of the EBV-early-antigen-complex as well as the approximately 27 EBV genome equivalents per tumour cell, demonstrated by DNA-DNA hybridisation, characterised the tumour as true Burkitt lymphoma which is observed extremely seldom outside Africa.
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