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  • Title: Cooperation of cytochalasin D and anti-microtubular agents in stimulating superoxide anion production in polymorphonuclear leukocytes.
    Author: Okamura N, Hanakura K, Kodakari M, Ishibashi S.
    Journal: J Biochem; 1980 Jul; 88(1):139-44. PubMed ID: 6251033.
    Abstract:
    Superoxide anion production in polymorphonuclear leukocytes obtained from guinea pig peritoneal cavities was stimulated by treatment with 5 microgram/ml of cytochalasin D in vitro. The stimulation was further enhanced by the addition of either 10(-5)-10(-7) M vinblastine or 10(-3)-10(-8) M colchicine to cytochalasin D. Higher concentrations of these anti-microtubular agents were inhibitory to the stimulating effect of cytochalasin D on the superoxide anion production, while lower concentrations had almost no effect. In the resting leukocytes, i.e. without cytochalasin D, the anti-microtubular agents by themselves had no effect on the superoxide anion production. The cooperation of cytochalasin D and the anti-microtubular agents was also observed in the stimulation of NADPH oxidase activity and bactericidal function of the leukocytes.
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