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  • Title: Expression of SV40 tumor antigen in SV40 transformed teratocarcinoma-derived cell lines.
    Author: Axelrod HR, Levine AJ.
    Journal: J Cell Physiol; 1980 Aug; 104(2):249-52. PubMed ID: 6251099.
    Abstract:
    The relative importance of viral tumor antigen expression and the cellular background in the maintenance of a transformation phenotype was examined in five SV40-transformed teratocarcinoma-derived cell lines. These cell lines show qualitative differences in growth characteristics associated with transformation, and vary in their state of differentiation. Viral T antigen expression was evaluated by two criteria: 1) the amount of immunoprecipitated antigen in growing cells, and 2) the amount and rate of antigen synthesis in density-inhibited cells. There was no direct correlation found between retention, or rate of synthesis, of the viral T antigen and the degree of transformation. These findings imply that the cellular environment has a more important influence on the growth properties of a stably transformed cell than the quantitative levels of viral T antigen expression.
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