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  • Title: Effect of oxidizing agents and sulfhydryl group reagents on beta toxin from Clostridium perfringens type C.
    Author: Sakurai J, Fujii Y, Matsuura M.
    Journal: Microbiol Immunol; 1980; 24(7):595-601. PubMed ID: 6251344.
    Abstract:
    Purified beta toxin from Clostridium perfringens type C was inactivated by the oxidizing agents o-iodosobenzoate (OIBA), oxidized glutathione, and ferricyanide, and by the sulfhydryl group regents 5,5'-dithio-bis(2-nitrobenzoic acid) (DTNB) and N-ethylmaleimide, iodoacetamide, and iodoacetic acid, causing loss of activity in various degrees depending on the concentration used. The activity of the toxin was not influenced by exposure to 1.0 mM of p-chloromercuribenzoate. The toxin treated by OIBA or DTNB was reactivated by incubation with 2-mercaptoethanol and dithiothreitol. The data suggest that beta toxin contains thiol groups which are essential for the activity.
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