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  • Title: Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding.
    Author: Peroutka SJ, Snyder SH.
    Journal: Science; 1980 Oct 03; 210(4465):88-90. PubMed ID: 6251550.
    Abstract:
    Antidepressants compete at several neurotransmitter receptor binding site, but drug affinities do not correlate with clinical efficacy. Long-term, but not short-term, antidepressant treatment decreases the numbers of both serotonin and beta-adrenergic receptors. The decrease in the number of receptor sites is most marked for [3H]spiroperidol-labeled serotonin receptors and is characteristic for antidepressants of several classes.
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