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  • Title: The mechanical and biochemical effects of pentoxifylline on the perfused rat heart.
    Author: Vittone L, Chiappe LE, Argel MI, Cingolani HE, Chiappe GE.
    Journal: Experientia; 1980 Sep 15; 36(9):1088-90. PubMed ID: 6252042.
    Abstract:
    Perfusion of the isolated rat heart at constant heart rate and coronary flow with the inhibitor of cyclic nucleotide phosphodiesterase, pentoxifylline (10(-4) moles/l), produced no significant effect on the maximum rate and the peak of contraction, but increased the maximum rate of relaxation. cAMP level and cAMP-dependent protein kinase activity were increased in the absence of changes in cGMP. The results were identical in hearts of reserpinized rats.
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