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  • Title: Resolution, reconstitution and kinetics of the primary action of a hormone receptor.
    Author: Citri Y, Schramm M.
    Journal: Nature; 1980 Sep 25; 287(5780):297-300. PubMed ID: 6252471.
    Abstract:
    The beta-adrenergic receptor (R) and the GTP binding protein (G) with which the receptor interacts were obtained in separate soluble fractions. Their recombination produced a hormone responsive system. In the presence of hormone the encounter of R with G in the reconstituted membrane occurs much faster than the subsequent R-induced activation of G.
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