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  • Title: [Mixed cryoglobulinaemia and benign monoclonal gammopathy in Sjogren's syndrome (author's transl)].
    Author: Clerc D, Segond P, Sallière D, Margulis J, Bisson M, Massias P.
    Journal: Sem Hop; ; 56(29-32):1290-2. PubMed ID: 6252617.
    Abstract:
    The authors report a case of Sjögren's syndrome associated with Raynaud phenomenon and mixed IgM-IgG cryoglobulinaemia. Three years after the onset of this association:--Immunoelectrophoresis of the serum showed a monoclonal IgM (lambda) protein, --the level of the mixed IgM-IgG cryoglobulinaemia had increased from 28 mcg/ml up to 12 mg/ml and its IgM component was monoclonal (lambda) with anti-IgG activity. Search for amyloïdosis and for a malignant lymphoma was negative. Such an association of a benign monoclonal gammopathy, mixed cryoglobulinaemia and Sjögren's Syndrome has only exceptionally been reported in the literature.
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