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  • Title: [Change in the cyclic nucleotide system components in neurogenic myopathies].
    Author: Khokhlov AP, Malakhovskiĭ VK.
    Journal: Vopr Med Khim; 1980; 26(5):640-3. PubMed ID: 6252689.
    Abstract:
    Values of Kdiss of the "protein kinase-cAMP" complex were decreased 2-6-fold in muscular tissue of patients with neurogenic myopathies. An increase in affinity of the protein kinase to cAMP correlated with the severity of the disease. Alteration in the cAMP-sGMP ratio, due to decrease in cGMP content, was found in patients with side amyotrophic sclerosis.
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