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  • Title: [Antibodies to rubella virus in the blood sera and in the synovial fluid of children with rheumatoid arthritis].
    Author: Lozovskaia LS, Desiatskova RG, Mitchenko AF, Pokryshkina EL, Shigina OM.
    Journal: Vopr Virusol; 1980; (4):468-73. PubMed ID: 6252699.
    Abstract:
    Sera and synovial fluids from children with rheumatoid arthritis (RA) were examined for antibody to some viral and mycoplasmal antigens. Blood sera from the patients were found to have a selective excess of antibody to rubella virus as compared with the age norm. Antibody of this specificity was found in synovial fluids in titers significantly higher than those in the blood. Titers of other antibodies in the synovial fluids were, as a rule, slightly lower than in sera. In the time course of intercurrent respiratory diseases, despite the lack of rubella introduction into the wards, children with RA showed variations in the levels of antibody to rubella virus much more frequently than to other infectious agents. The foregoing data are discussed from the point of view of the etiological association of juvenile RA with rubella virus persistence. The antigen of the latter was found in snyovial membrane cells of 4 children by means of immunofluorescence procedure.
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