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  • Title: L-Ethionine as an inducer of differentiation in human promyelocytic leukemia cells (HL-60).
    Author: Mendelsohn N, Michl J, Gilbert HS, Acs G, Christman JK.
    Journal: Cancer Res; 1980 Sep; 40(9):3206-10. PubMed ID: 6253057.
    Abstract:
    The methionine analog, L-ethionine, induces morphological and biochemical changes in cultured HL-60 cells which are indicative of myeloid maturation. After 3 to 5 days of growth in the presence of L-ethionine, the majority of cells have enhanced phagocytic ability. The percentage of cells in the culture which bear complement receptors and which can respond to 12-O-tetradecanoylphorbol-13-acetate with respiratory burst activity increases more than 3-fold. Since the cells fail to become adherent and lose nonspecific esterase activity, we conclude that L-ethionine, like dimethyl sulfoxide, induces granulocytic differentiation of HL-60 cells.
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