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  • Title: Growth-related alterations induced in chick embryo fibroblasts by src-gene deletion mutants of the Schmidt-Ruppin strain of Rous sarcoma virus.
    Author: Breitman ML, Vigne R, Vogt PK.
    Journal: Cold Spring Harb Symp Quant Biol; 1980; 44 Pt 2,():1047-55. PubMed ID: 6253179.
    Abstract:
    Certain tdSRD viruses induce multilayered cell foci, agar colony formation, and increased density of cellular populations in line-15 chick embryo fibroblasts. These alterations in cellular growth properties are distinct from oncogenic transformation. Available evidence favors the idea that transformation-defective focus formation is caused by one or more of the replicative viral genes, but which of the three-gag, pol, or env-is involved, remains to be determined.
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