These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Hepatic insensitivity to glucagon in ob/ob mice.
    Author: Yen TT, Stamm NB, Fuller RW, Root MA.
    Journal: Res Commun Chem Pathol Pharmacol; 1980 Oct; 30(1):29-40. PubMed ID: 6254120.
    Abstract:
    Hepatic cAMP concentration of normal mice increased 40 fold within 10 min after a single dose of glucagon (2 mg/kg, IP). In contrast, hepatic cAMP increased only 2 fold in ob/ob mice. Glucagon induced hepatic L-phenylalanine:pyruvate aminotransferase and stimulated glycogenolysis in normal mice but failed to elicit these cAMP-mediated responses in ob/ob mice. The insensitivity of ob/ob mice to glucagon was not ameliorated by fasting or by theophylline.
    [Abstract] [Full Text] [Related] [New Search]