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  • Title: Modulation of epidermal growth factor receptors on 3T3 cells by platelet-derived growth factor.
    Author: Wrann M, Fox CF, Ross R.
    Journal: Science; 1980 Dec 19; 210(4476):1363-5. PubMed ID: 6254158.
    Abstract:
    Platelet-derived growth factor does not compete with epidermal growth factor (EGF) for binding to EGF receptors on the murine 3T3 cell surface, but it modulates EGF receptors in two ways: (i) it induces a transient down regulation of EGF receptors and (ii) it inhibits EGF-induced down regulation of EGF receptors. These data suggest a common cellular internalization mechanism for the receptors for both hormones.
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