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  • Title: The in vitro metabolism of 2,2',4,4',5,5'-hexabromobiphenyl.
    Author: Purdy R, Safe S.
    Journal: J Environ Pathol Toxicol; 1980 Aug; 4(1):277-84. PubMed ID: 6255052.
    Abstract:
    Radiolabelled 2,2',4,4',5,5'-hexabromobiphenyl was metabolized in vitro by rat liver microsomal enzymes to give more polar ether soluble lipophilic metabolites, trichloroacetic acid soluble conjugates and a macromolecular adduct fraction. The rates of formation of the three metabolic fractions were significantly enhanced using Firemaster BP-6 and 2,2',4,4',5,5'-hexabromobiphenyl induced microsomal enzymes. Comparative metabolic studies with the 4-brombiphenyl substrate showed that the lower brominated biphenyl substrate was more readily metabolized and the rate of metabolism was enhanced only with the Firemaster BP-6 induced microsomal enzymes and not the 2,2', 4,4',5,5'-hexabromobiphenyl induced enzyme system.
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