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  • Title: [Features of the kinetic and stationary characteristics of aconitine-modified sodium channels].
    Author: Mozhaeva GN, Naumov AP, Nosyreva ED.
    Journal: Neirofiziologiia; 1980; 12(6):612-8. PubMed ID: 6255354.
    Abstract:
    Kinetic and steady-state characteristics of aconitine-modified sodium channels were studied in the Ranvier node membrane. Aconitine-modified sodium channels are shown to be inactivated only partially. The voltage dependence of the fraction of noninactivated channels (h infinity) may be described by a three-state model of the channel with closed, open and inactivated states. A reasonable agreement with the data was obtained when parameters of the inactivated state were supposed to be not changed after aconitine modification of the channels. The membrane repolarization to -70 divided by -110 mV, after long (10 ms) depolarizing shift induces firstly fast current decay ("tail") and then its rather slow increase to a steady-state level. Kinetics of this current requires two or more open states to be postulated.
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