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  • Title: Erythrocyte membrane cation carrier in manic-depressive psychosis.
    Author: Naylor GJ, Smith AH, Dick EG, Dick DA, McHarg AM, Chambers CA.
    Journal: Psychol Med; 1980 Aug; 10(3):521-5. PubMed ID: 6255506.
    Abstract:
    Erythrocyte Na-K ATPase and sodium pump site numbers were estimated in groups of depressed, manic and recovered patients. The activity of Na-K ATPase per pump site was lower in the depressed group than in the recovered group. In the manic group Na-K ATPase was lower than that of the recovered group, whereas there was no difference in the pump site numbers. In the more severe manics the activity of Na-K ATPase per pump site was significantly lower than that of the recovered patients. Therefore, the change occurring in the erythrocyte membrane cation carrier in manic-depressive psychosis is probably in the activity of individual Na-K ATPase molecules and not in the number of Na-K ATPase molecules per cell.
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