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  • Title: Effect of levamisole on lysosomal enzyme release from polymorphonuclear leukocytes and intracellular levels of cAMP and cGMP after phagocytosis of monosodium urate crystals.
    Author: Mikulíková D, Trnavský K.
    Journal: Agents Actions; 1980 Sep; 10(4):374-7. PubMed ID: 6255776.
    Abstract:
    In order to study the influence of levamisole on lysosomal enzyme release, human polymorphonuclear (PMN) leukocytes were incubated with 0.5 mg/ml monosodium urate crystals. The release of neutral proteinase, beta glucuronidase, myeloperoxidase and lactic dehydrogenase as cytoplasmatic marker was measured. Preincubation of PMN with various concentrations of levamisole lasting 1 h resulted in a decrease of all enzymes released. Intracellular levels of both cyclic nucleotides--cAMP and cGMP--rose in PMN preincubated with levamisole, in comparison with untreated cells.
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