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  • Title: Selective inhibition of protein synthetic activity of cerebral membrane-bound ribosomes as a consequence of ethanol ingestion.
    Author: Khawaja JA, Lindholm DB, Niittylä J.
    Journal: Res Commun Chem Pathol Pharmacol; 1978 Jan; 19(1):185-8. PubMed ID: 625591.
    Abstract:
    Ethanol ingestion by weanling rats results in an inhibition of protein synthetic activity of cerebral membrane-bound ribosomes. Among various amino acids tested, the incorporation of serine was inhibited to a maximum degree. In contrast to membrane-bound ribosomes, the activity of free ribosomes was enhanced as a consequence of ethanol treatment. Aminoacylation of tRNA in pH 5 fraction was also reduced in the brain cortices of ethanol-fed animals.
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