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  • Title: Failure of neostigmine to prevent tubocurarine neuromuscular block in the isolated arm.
    Author: Feldman SA, Agoston S.
    Journal: Br J Anaesth; 1980 Dec; 52(12):1199-1203. PubMed ID: 6255977.
    Abstract:
    Neostigmine failed to modify the development of neuromuscular block in the presence of a high local concentration of tubocurarine. Only when the concentration of tubocurarine was reduced, and a suitable concentration gradient established between the receptor area and the plasma, did neostigmine increase the rate of recovery from the action of non-depolarizing neuromuscular blocking agents.
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