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  • Title: Binding of 3H-beta-endorphin to rat brain membranes: characterization of opiate properties and interaction with ACTH.
    Author: Akil H, Hewlett WA, Barchas JD, Li CH.
    Journal: Eur J Pharmacol; 1980 May 30; 64(1):1-8. PubMed ID: 6256172.
    Abstract:
    The binding of tritiated beta-endorphin (3H-beta-EP) to brain homogenates is described. This has been difficult to achieve due to the lack of availability of 3H-beta-EP and to technical difficulties associated with high non-specific binding of beta-EP. We now report that 3H-beta-EP binding is saturable, stereospecific, has high affinity and is inhibited by sodium. Its dissociation rate is ten-fold longer than that of naloxone. Its regional distribution exhibits interesting differences from naloxone and enkephalin binding. ACTH1-24 appears to displace it more effectively than it displaces 3H-naloxone. The results are discussed in terms of multiple transmitter systems and the multiple opiate receptor hypothesis.
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