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Title: Effects of N-ethylmaleimide treatment on the action potential Na+-ionophore of cultured neuroblastoma cells. Author: Panini A, Blumenthal K. Journal: J Neurochem; 1980 Sep; 35(3):707-12. PubMed ID: 6256495. Abstract: Treatment of murine neuroblastoma N18 cells with N-ethylmaleimide under conditions that favor diminution of membrane potential leads to a 65% increase in the rate of veratridine-stimulated, tetrodotoxin-sensitive Na+ uptake and to a 50% decrease in the concentration of veratridine required for half-maximal stimulation. This modification does not appear to occur in N18 cells having a normal membrane potential of approx. -40 mV. The data are consistent with the involvement of a sulfhydryl group in the Na+ channel inactivation gate and in the conformational change in this gate which results in closing of the channel.[Abstract] [Full Text] [Related] [New Search]