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  • Title: Labetalol in long-term treatment of hypertension.
    Author: Prichard BN, Boakes AJ.
    Journal: Br J Clin Pharmacol; 1976 Aug; 3(4 Suppl 3):743-50. PubMed ID: 62582.
    Abstract:
    1 Labetalol, a beta- and alpha-adrenoreceptor-blocking drug, has been used in the treatment of hypertension in a total of 32 patients for over 4.5 yr, 14 patients for 3 yr or more. 2 Labetalol seems to have a similarly potency of methyldopa and the adrenergic neurone-blocking drugs. 3 Postural hypotension was only observed at doses over 2 g/d. It was the reason for stopping treatment in two patients. 4 Dosage varied; average 889 mg/d, range 75-3,200 mg. Tolerance did not develop. 5 Side-effects led to drug withdrawal in four patients
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