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  • Title: [Changes in the activity of cyclic adenosine monophosphate metabolism enzymes in myocardial hypertrophy and after exposure to hyperbaric oxygenation].
    Author: Miroshnichenko VP, Zubovskaia AM, Grigorovich IuA, Demurov EA, Koloskov IuB.
    Journal: Vopr Med Khim; 1981; 27(1):112-5. PubMed ID: 6258317.
    Abstract:
    Hypertrophy of myocardium, developed within 4 weeks after aorta stenosis, led to alteration in content of adrenaline in heart tissue as well as in some pathways of cAMP turnover: decrease in content of cAMP, an increase in the basal activity of adenylate cyclase, decrease in activation of the enzyme by adrenaline; activity of phosphodiesterase was not distinctly altered. Under conditions of hyperbaric oxygenation hypertrophy of myocardium became less distinct, content of cAMP was increased up to the normal value, the increased basal activity of adenylate cyclase was slightly decreased, whereas sensitivity of the enzyme to adrenaline did not reduce, content of adrenaline was increased.
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