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  • Title: [Effect of histones on mouse liver mitochondria cytochrome oxidase activity in vitro and in vivo].
    Author: Risin SA.
    Journal: Vopr Med Khim; 1981; 27(1):56-9. PubMed ID: 6258323.
    Abstract:
    Histones at concentration of 2-10 micrograms/ml activated the mitochondrial cytochrome oxidase and at concentration of 25 micrograms/ml and higher--inhibited the enzyme in vitro. Cytochrome oxidase was completely inactivated by histones at concentration of 100 mg/microliter and higher. After administration in vivo histones modified the reaction of liver mitochondria in response to the subsequent treatment with a non-ion detergent Triton X-100. Possible pathogenetic importance of the phenomena observed is discussed.
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