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  • Title: [Results of clinical application of methods of individual selection of chemotherapeutic preparations in the treatment of gliomas].
    Author: Apshkalne DL, Kruminia GA, Kikut RP, Kotel'nikov VM.
    Journal: Zh Vopr Neirokhir Im N N Burdenko; 1980; (6):7-12. PubMed ID: 6258363.
    Abstract:
    The method of autoradiography for testing the efficacy of cytostatics with subsequent individually chosen chemotherapy is one of the components of rational therapy for neuro-oncological patients. Purposeful chemotherapy was applied in 17 cases with gliomas. Favourable results were recorded in 70.6% of them. Twelve patients received regular courses of treatment with one agent which inhibited DNA synthesis in vitro most potently (in 7 the therapeutic result was favourable), 5 patients were given course of polychemotherapy (favourable effect in 100%). Prolonged survival and a good remission allow autoradiography to be recommended as a method for the individual choice of antiblastic agents.
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