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  • Title: Evidence that the opiate receptors of the substantia gelatinosa contribute to the depression, by intravenous morphine, of the spinal transmission of impulses in unmyelinated primary afferents.
    Author: Johnson SM, Duggan AW.
    Journal: Brain Res; 1981 Feb 23; 207(1):223-8. PubMed ID: 6258733.
    Abstract:
    In barbiturate anaesthetized cats, dorsal horn neurones were excited by electrical stimulation of the common tibial nerve. The numbers of action potentials evoked by excitation of C fibres were depressed by analgesic doses of morphine (1-4 mg/kg i.v.). Naloxone, administered electrophoretically in the substantia gelatinosa, fully reversed the inhibitory action of morphine. The results suggest that opiate receptors in the substantia gelatinosa play a role in morphine analgesia.
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