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  • Title: Histamine actions on activity of cultured hypothalamic neurons: evidence for mediation by H1- and H2-histamine receptors.
    Author: Geller HM.
    Journal: Brain Res; 1981 Jan; 227(1):89-101. PubMed ID: 6258751.
    Abstract:
    Tuberal hypothalamic tissue cultures were used to investigate the actions of histaminergic agents on neuronal activity using extracellular glass micropipettes. Histamine and H1- and H2-agonists were applied locally onto single active neurons by iontophoresis, while histaminergic antagonists were perfused through the bathing medium. Peri-event histogram and ratemeter analysis showed histamine to both excite and depress unit activity. Excitations were only antagonized by putative H1- and not H2-histamine antagonists, whereas inhibitions were antagonized by H2- and H2-antagonists. Dimaprit, a specific H2-agonist, elicited inhibitions of activity, while 2-(2-pyridyl)ethylamine, a putative H1-agonist, elicited both excitations and inhibitions. Two pharmacologically distinct populations of histamine receptors may exit in the hypothalamus: excitatory H2-receptors and inhibitory H2-receptors.
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